Circulating blood is filtered across the glomerular barrier to form an ultrafiltrate of plasma in
the Bowman's space. The volume of glomerular filtration adjusted by time is defined as the …

Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal,
monogenic disorder. It is associated with large interfamilial and intrafamilial variability, which …

The rate of renal disease progression varies widely among patients with autosomal
dominant polycystic kidney disease (ADPKD), necessitating optimal patient selection for …

Background: Equations to estimate glomerular filtration rate (GFR) are routinely used to
assess kidney function. Current equations have limited precision and systematically …

An equation from the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)
provides more accurate estimates of the glomerular filtration rate (eGFR) than that from the …

Background Angiomyolipomas in patients with the tuberous sclerosis complex or sporadic
lymphangioleiomyomatosis are associated with mutations in tuberous sclerosis genes …

Background Autosomal dominant polycystic kidney disease (ADPKD) is a slowly
progressive hereditary disorder that usually leads to end-stage renal disease. Although the …

Background In autosomal dominant polycystic kidney disease (ADPKD), aberrant activation
of the mammalian target of rapamycin (mTOR) pathway is associated with progressive …

Autosomal dominant polycystic kidney disease is one of the most common hereditary
disorders, being 10 times more common than sickle cell disease, 15 times more common …

Results After a mean follow-up of 7.9 years, stage 3 CKD was attained in 30.7% of the
enrollees. Using baseline htTKV, negative correlations with GFR increased from− 0.22 at …