In recent years, studies on the intracellular pathogen Francisella tularensis have greatly
intensified, generating a wealth of new information on the interaction of this organism with …

Francisella tularensis can cause fatal respiratory tularemia in humans and animals and is
increasingly being isolated in the United States and several European countries. The …

Macrophage produced inducible nitric oxide synthase (iNOS) is known to play a critical role
in the proinflammatory response against intracellular pathogens by promoting the …

Many aspects of pathogenic granuloma formation are poorly understood, requiring new
relevant laboratory models that represent the complexity (genetics and diversity) of human …

Infectious diseases represent one of the largest medical challenges worldwide. Bacterial
infections, in particular, remain a pertinent health challenge and burden. Moreover, such …

Members of the bacterial genus Francisella are highly virulent and infectious pathogens.
New models to study Francisella pathogenesis in evolutionarily distinct species are needed …

Tularaemia is a zoonotic disease caused by the Gram-negative bacterium, Francisella
tularensis. Depending on its entry route into the organism, F. tularensis causes different …

Although Francisella tularensis subsp. tularensis is known to cause extensive tissue
necrosis, the pathogenesis of tissue injury has not been elucidated. To characterize cell …

There is increasing evidence that opiates accelerate the pathogenesis and progression of
acquired immunodeficiency syndrome (AIDS), as well as the incidence of human …

Francisella tularensis (Ft) is a gram-negative intercellular pathogen and category A biothreat
agent. However, despite 15 years of strong government investment and intense research …