Regulated exocytosis of secretory granules or dense-core granules has been examined in
many well-characterized cell types including neurons, neuroendocrine, endocrine, exocrine …

Stimulus-secretion coupling is an essential process in secretory cells in which regulated
exocytosis occurs, including neuronal, neuroendocrine, endocrine, and exocrine cells. While …

The adenylyl cyclases are variously regulated by G protein subunits, a number of
serine/threonine and tyrosine protein kinases, and Ca2+. In some physiological situations …

The vanilloid receptor-1 (TRPV1) plays a key role in the perception of peripheral thermal
and inflammatory pain. TRPV1 expression and channel activity are notably up-regulated by …

The terminal step in cytokinesis, called abscission, requires resolution of the membrane
connection between two prospective daughter cells. Our previous studies demonstrated that …

Botulinum toxin (BoNT) is a potent neurotoxin that is produced by the gram-positive, spore-
forming, anaerobic bacterium, Clostridum botulinum. There are 7 known immunologically …

Molecules involved in late steps of neurotransmitter release at the synapse can be
examined by noting the two speeds of the components of the exocytotic burst that are …

The kidney plays an essential role in blood pressure regulation by controlling short-term and
long-term NaCl and water balance. The thick ascending limb of the loop of Henle (TAL) …

Protein kinase A (PKA) is a key regulator of neurosecretion, but the molecular targets remain
elusive. We combined pharmacological manipulations of kinase and phosphatase activities …

A longstanding hypothesis is that ion channels are present in the membranes of synaptic
vesicles and might affect neurotransmitter release. Here we demonstrate that TRPM7, a …