Pseudomonas aeruginosa transcriptome analysis of metal restriction in ex vivo cystic fibrosis sputum
Chronic Pseudomonas aeruginosa lung infections are a feature of cystic fibrosis (CF) that
many patients experience even with the advent of highly effective modulator therapies …
many patients experience even with the advent of highly effective modulator therapies …
The power of weak, transient interactions across biology: A paradigm of emergent behavior
A growing list of diverse biological systems and their equally diverse functionalities provides
realizations of a paradigm of emergent behavior. In each of these biological systems …
realizations of a paradigm of emergent behavior. In each of these biological systems …
Rocket-miR, a translational launchpad for miRNA-based antimicrobial drug development
Developing software tools that leverage biological data sets to accelerate drug discovery is
an important aspect of bioinformatic research. Here, we present a novel example: a web …
an important aspect of bioinformatic research. Here, we present a novel example: a web …
Effects of mucin and DNA concentrations in airway mucus on Pseudomonas aeruginosa biofilm recalcitrance
The pathological properties of airway mucus in cystic fibrosis (CF) are dictated by mucus
concentration and composition, with mucins and DNA being responsible for mucus …
concentration and composition, with mucins and DNA being responsible for mucus …
Clostridioides difficile-mucus interactions encompass shifts in gene expression, metabolism, and biofilm formation
In a healthy colon, the stratified mucus layer serves as a crucial innate immune barrier to
protect the epithelium from microbes. Mucins are complex glycoproteins that serve as a …
protect the epithelium from microbes. Mucins are complex glycoproteins that serve as a …
[HTML][HTML] Extracellular DNA in sputum is associated with pulmonary function and hospitalization in patients with cystic fibrosis
TC Piva, C Luft, KH Antunes, PJC Marostica… - Respiratory …, 2020 - Elsevier
Background Elevated extracellular DNA levels are found in the sputum of patients with cystic
fibrosis (CF). However, studies investigating the association of extracellular DNA with CF …
fibrosis (CF). However, studies investigating the association of extracellular DNA with CF …