Androgens are essential sex steroid hormones for both sexes. Testosterone (T) is the
predominant androgen in males, while in adult females, T concentrations are about 15-fold …

Androgens are an important and diverse group of steroid hormone molecular species. They
play varied functional roles, such as the control of metabolic energy fate and partition, the …

For many decades, the prevailing paradigm in endocrinology was that testosterone and 5α-
dihydrotestosterone are the only potent androgens in the context of human physiology. The …

Testosterone, many steroidal androgens, and nonsteroidal ligands that bind to androgen
receptor and exert tissue-specific transcriptional activity (selective androgen receptor …

Endometrial cancer (EC) is a gynecological pathology that affects the uterine inner lining. In
recent years, genomic studies revealed continually evolving mutational landscapes of …

Testosterone biosynthesis from its precursor androstenedione is thought to be exclusively
catalysed by the 17β-hydroxysteroid dehydrogenases—HSD17B3 in testes, and AKR1C3 in …

Polycystic ovarian syndrome (PCOS) is a metabolic, reproductive, and psychological
disorder affecting 6–20% of reproductive women worldwide. However, there is still no cure …

Abstract Aldo‐keto reductase 1C3 (AKR1C3) is a key enzyme in the activation of both
classic and 11‐oxygenated androgens. In adipose tissue, AKR1C3 is co‐expressed with …

Context Recent evidence support that androgens play an important role in the etiology of
endometrial cancer (EC). Adrenal-derived 11-oxygenated androgens are highly potent …

Objective Androgen insensitivity syndrome (AIS) due to androgen receptor (AR) mutations
creates a spectrum of clinical presentations based on residual AR function with the mildest …