Non-coding RNAs expression in SARS-CoV-2 infection: pathogenesis, clinical significance, and therapeutic targets

X Liu, W Xiong, M Ye, T Lu, K Yuan, S Chang… - … and Targeted Therapy, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has been looming globally for
three years, yet the diagnostic and treatment methods for COVID-19 are still undergoing …

MicroRNAs modulate neuroinflammation after intracerebral hemorrhage: Prospects for new therapy

S Xia, Y Zheng, F Yan, G Chen - Frontiers in Immunology, 2022 - frontiersin.org
Intracerebral hemorrhage (ICH) is the most common subtype of hemorrhagic stroke. After
ICH, blood components extravasate from vessels into the brain, activating immune cells and …

Mesenchymal stem cells successfully deliver oncolytic virotherapy to diffuse intrinsic pontine glioma

MI Chastkofsky, KC Pituch, H Katagi, M Zannikou… - Clinical Cancer …, 2021 - AACR
Purpose: Diffuse intrinsic pontine glioma (DIPG) is among the deadliest of pediatric brain
tumors. Radiotherapy is the standard-of-care treatment for DIPG, but offers only transient …

Controlling viral inflammatory lesions by rebalancing immune response patterns

S Mulik, E Berber, S Sehrawat, BT Rouse - Frontiers in Immunology, 2023 - frontiersin.org
In this review, we discuss a variety of immune modulating approaches that could be used to
counteract tissue-damaging viral immunoinflammatory lesions which typify many chronic …

Neural stem cells secreting bispecific T cell engager to induce selective antiglioma activity

KC Pituch, M Zannikou, L Ilut, T Xiao… - Proceedings of the …, 2021 - National Acad Sciences
Glioblastoma (GBM) is the most lethal primary brain tumor in adults. No treatment provides
durable relief for the vast majority of GBM patients. In this study, we've tested a bispecific …

MicroRNA-124/Death-Associated Protein Kinase 1 Signaling Regulates Neuronal Apoptosis in Traumatic Brain Injury via Phosphorylating NR2B

Y Shi, W Cui, Q Wang, J Zhou, X Wu, J Wang… - Frontiers in Cellular …, 2022 - frontiersin.org
Death-associated protein kinase 1 (DAPK1), a Ca2+/calmodulin-dependent
serine/threonine-protein kinase, promotes neurons apoptosis in ischemic stroke and …

A unified framework for the prediction of small molecule–MicroRNA association based on cross-layer dependency inference on multilayered networks

CC Wang, X Chen - Journal of chemical information and modeling, 2019 - ACS Publications
MicroRNAs (miRNAs) play a key role in many critical biological processes and are involved
in the occurrence and development of complex human diseases. Many studies …

Reduction in miR‐219 expression underlies cellular pathogenesis of oligodendrocytes in a mouse model of Krabbe disease

N Inamura, S Go, T Watanabe, H Takase… - Brain …, 2021 - Wiley Online Library
Krabbe disease (KD), also known as globoid cell leukodystrophy, is an inherited
demyelinating disease caused by the deficiency of lysosomal galactosylceramidase (GALC) …

Resilience in long-term viral infection: genetic determinants and interactions

C Brinkmeyer-Langford, K Amstalden… - International Journal of …, 2021 - mdpi.com
Virus-induced neurological sequelae resulting from infection by Theiler's murine
encephalomyelitis virus (TMEV) are used for studying human conditions ranging from …

Expression of microRNAs targeting heat shock protein B8 during in vitro expansion of dental pulp stem cells in regulating osteogenic differentiation

S Yao, C Li, AM Budenski, P Li, A Ramos, S Guo - Archives of oral biology, 2019 - Elsevier
Objective The objectives of this study were (a) to determine the differentially expressed
microRNAs that can target heat shock protein B8 (HspB8) during in vitro expansion of dental …