[HTML][HTML] Control of the embryonic stem cell state
RA Young - Cell, 2011 - cell.com
Embryonic stem cells and induced pluripotent stem cells hold great promise for regenerative
medicine. These cells can be propagated in culture in an undifferentiated state but can be …
medicine. These cells can be propagated in culture in an undifferentiated state but can be …
[HTML][HTML] Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put
JA Simon, RE Kingston - Molecular cell, 2013 - cell.com
Chromatin modification by Polycomb proteins provides an essential strategy for gene
silencing in higher eukaryotes. Polycomb repressive complexes (PRCs) silence key …
silencing in higher eukaryotes. Polycomb repressive complexes (PRCs) silence key …
Reprogramming of H3K9me3-dependent heterochromatin during mammalian embryo development
Abstract H3K9me3-dependent heterochromatin is a major barrier of cell fate changes that
must be reprogrammed after fertilization. However, the molecular details of these events are …
must be reprogrammed after fertilization. However, the molecular details of these events are …
[HTML][HTML] The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse
The histone-modifying complexes PRC2 and TrxG/MLL play pivotal roles in determining the
activation state of genes controlling pluripotency, lineage commitment, and cell …
activation state of genes controlling pluripotency, lineage commitment, and cell …
[HTML][HTML] Braveheart, a long noncoding RNA required for cardiovascular lineage commitment
CA Klattenhoff, JC Scheuermann, LE Surface… - Cell, 2013 - cell.com
Long noncoding RNAs (lncRNAs) are often expressed in a development-specific manner,
yet little is known about their roles in lineage commitment. Here, we identified Braveheart …
yet little is known about their roles in lineage commitment. Here, we identified Braveheart …
Retinoic acid receptors: from molecular mechanisms to cancer therapy
Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …
Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer
M Sauvageau, G Sauvageau - Cell stem cell, 2010 - cell.com
Polycomb Group (PcG) proteins are transcriptional repressors that epigenetically modify
chromatin and participate in the establishment and maintenance of cell fates. These proteins …
chromatin and participate in the establishment and maintenance of cell fates. These proteins …
[HTML][HTML] Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network
The embryonic stem (ES) cell transcriptional and chromatin-modifying networks are critical
for self-renewal maintenance. However, it remains unclear whether these networks …
for self-renewal maintenance. However, it remains unclear whether these networks …
Analysis of transcriptional variability in a large human iPSC library reveals genetic and non-genetic determinants of heterogeneity
Variability in induced pluripotent stem cell (iPSC) lines remains a concern for disease
modeling and regenerative medicine. We have used RNA-sequencing analysis and linear …
modeling and regenerative medicine. We have used RNA-sequencing analysis and linear …
[HTML][HTML] Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells
Numerous chromatin regulators are required for embryonic stem (ES) cell self-renewal and
pluripotency, but few have been studied in detail. Here, we examine the roles of several …
pluripotency, but few have been studied in detail. Here, we examine the roles of several …