Matrix metalloproteinases (MMPs), originally discovered to function in the breakdown of
extracellular matrix proteins, have gained the status of regulatory proteases in signaling …

The blood–brain barrier (BBB) provides significant protection against microbial invasion of
the brain. However, the BBB is not impenetrable, and mechanisms by which viruses breach …

Blood–brain barrier (BBB) disruption, resulting from loss of tight junctions (TJ) and activation
of matrix metalloproteinases (MMPs), is associated with edema formation in ischemic stroke …

Rationale: Secondary bacterial infection following rhinovirus (RV) infection has been
recognized in chronic obstructive pulmonary disease. Objectives: We sought to understand …

Vascular endothelial growth factor (VEGF) alters tight junctions (TJs) and promotes vascular
permeability in many retinal and brain diseases. However, the molecular mechanisms of …

Barrier dysfunction in inflammatory bowel disease contributes to diarrhea by a leak flux
mechanism and can cause mucosal inflammation secondary to luminal antigen uptake …

The inflammatory bowel diseases (IBD) are comprised of two major phenotypes, Crohn's
disease (CD) and ulcerative colitis (UC). Research over the last couple of years has led to …

The gastrointestinal barrier is-with approximately 400 m 2-the human body's largest surface
separating the external environment from the internal milieu. This barrier serves a dual …

Listeria monocytogenes causes invasive disease by crossing the intestinal epithelial barrier.
This process depends on the interaction between the bacterial surface protein Internalin A …

The family of more than 20 claudin (CLDN) proteins comprises one of the major structural
elements within the apical tight junction apparatus, a dynamic cellular nexus for …