The number of successful drug development projects has been stagnant for decades
despite major breakthroughs in chemistry, molecular biology, and genetics. Unreliable target …

Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have enormous potential
for the study of human cardiac disorders. However, their physiological immaturity severely …

Human induced pluripotent stem cells (hiPSCs) have emerged as a promising platform for
pharmacogenomics and drug development. In cardiology, they make it possible to produce …

Rationale: Diabetes mellitus is a complex, multisystem disease, affecting large populations
worldwide. Chronic CaMKII (Ca2+/calmodulin-dependent kinase II) activation may occur in …

Cardiotoxicity has historically been a major cause of drug removal from the pharmaceutical
market. Several chemotherapeutic compounds have been noted for their propensities to …

Cardiomyocytes undergo significant structural and functional changes after birth, and these
fundamental processes are essential for the heart to pump blood to the growing body …

Rationale: Calcium transient analysis is central to understanding inherited and acquired
cardiac physiology and disease. Although the development of novel calcium reporters …

Drug safety initiatives have endorsed human iPSC-derived cardiomyocytes (hiPSC-CMs) as
an in vitro model for predicting drug-induced cardiac arrhythmia. However, the extent to …

Modeling cardiac disorders with human induced pluripotent stem cell (hiPSC)-derived
cardiomyocytes is a new paradigm for preclinical testing of candidate therapeutics …

All cells maintain ionic gradients across their plasma membranes, producing
transmembrane potentials (Vmem). Mounting evidence suggests a relationship between …