Apelin is a natural ligand for the G protein-coupled receptor APJ, and the apelin/APJ system
is widely distributed in vivo. Among the apelin family, apelin-13 is the major apelin isoform in …

Apelin and apela (ELABELA/ELA/Toddler) are two peptide ligands for a class A G-protein-
coupled receptor named the apelin receptor (AR/APJ/APLNR). Ligand-AR interactions have …

Apelin-13 is a novel endogenous ligand for an angiotensin-like orphan G-protein coupled
receptor, and it may be neuroprotective against cerebral ischemia injury. However, the …

Apelin, the endogenous ligand of the G protein-coupled APJ receptor, is a peptide mediator
with emerging regulatory actions in the heart. We aimed to determine whether the …

The adipocytokine apelin and its G protein-coupled APJ receptor were initially isolated from
a bovine stomach and have been detected in the brain and cardiovascular system. Recent …

There are virtually no clinically available neuroprotective drugs for the treatment of acute
and chronic neurological disorders, hence there is an urgent need for the development of …

Adult regenerative myogenesis is vital for restoring normal tissue structure after muscle
injury. Muscle regeneration is dependent on progenitor satellite cells, which proliferate in …

Apelin is a peptide originally isolated from bovine stomach tissue extracts and identified as
an endogenous ligand of the APJ receptor; recent work showed that apelin ameliorates the …

Neurodegenerative diseases (NDs), such as Alzheimer's disease (AD), Parkinson's disease
(PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), are disorders …

Alzheimer's disease (AD) by progressive neurodegenerative pattern is associated with
autophagy stress which is suggested as a potential cause of amyloid β (Aβ) aggregation and …