Dementia in Down syndrome: unique insights for Alzheimer disease research
IT Lott, E Head - Nature Reviews Neurology, 2019 - nature.com
Virtually all adults with Down syndrome (DS) show the neuropathological changes of
Alzheimer disease (AD) by the age of 40 years. This association is partially due to …
Alzheimer disease (AD) by the age of 40 years. This association is partially due to …
The role of noradrenaline in cognition and cognitive disorders
Many aspects of cognition and behaviour are regulated by noradrenergic projections to the
forebrain originating from the locus coeruleus, acting through alpha and beta …
forebrain originating from the locus coeruleus, acting through alpha and beta …
Risk factors for Down syndrome
F Coppedè - Archives of toxicology, 2016 - Springer
Down syndrome (DS) originates, in most of the cases (95%), from a full trisomy of
chromosome 21. The remaining cases are due to either mosaicism for chromosome 21 or …
chromosome 21. The remaining cases are due to either mosaicism for chromosome 21 or …
ATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism
Although mitochondrial disorders are clinically heterogeneous, they frequently involve the
central nervous system and are among the most common neurogenetic disorders …
central nervous system and are among the most common neurogenetic disorders …
siRNA drug delivery across the blood–brain barrier in Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disease with a few FDA-
approved drugs that provide modest symptomatic benefits and only two FDA-approved …
approved drugs that provide modest symptomatic benefits and only two FDA-approved …
Rodent models in Down syndrome research: impact and future opportunities
Down syndrome is caused by trisomy of chromosome 21. To date, a multiplicity of mouse
models with Down-syndrome-related features has been developed to understand this …
models with Down-syndrome-related features has been developed to understand this …
The early presentation of dementia in people with Down syndrome: a systematic review of longitudinal studies
BA Lautarescu, AJ Holland, SH Zaman - Neuropsychology review, 2017 - Springer
Adults with Down syndrome (DS) are at a very high risk of developing early onset
Alzheimer's disease (AD) due to trisomy of chromosome 21. AD is preceded by a prolonged …
Alzheimer's disease (AD) due to trisomy of chromosome 21. AD is preceded by a prolonged …
Clinical and research application of fluid biomarkers in autosomal dominant Alzheimer's disease and Down syndrome
Autosomal dominant Alzheimer's disease (ADAD) and Down syndrome (DS) constitute
genetic forms of Alzheimer's disease (AD). The study of these forms has been crucial in …
genetic forms of Alzheimer's disease (AD). The study of these forms has been crucial in …
[HTML][HTML] Alzheimer's disease in Down syndrome: an overlooked population for prevention trials
The discovery that adults with Down syndrome (DS) have neuropathological features
identical to individuals with sporadic Alzheimer's disease (AD) played a key role in the …
identical to individuals with sporadic Alzheimer's disease (AD) played a key role in the …
Clinical aspects and biomarkers of Alzheimer's disease in Down syndrome
Alzheimer's disease (AD) may affect in excess of 90% of individuals with Down syndrome
(DS) after age 60, due to duplication of the APP gene in trisomy of chromosome 21, with …
(DS) after age 60, due to duplication of the APP gene in trisomy of chromosome 21, with …