The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

Summary γδ T cells comprise the third cell lineage of lymphocytes that use, like αβ T cells
and B cells, V (D) J gene rearrangement with the potential to generate a highly diverse T cell …

Developmental thymic waves of innate-like and adaptive-like γδ T cells have been
described, but the current understanding of γδ T cell development is mainly limited to mouse …

Accumulating evidence suggests that the mouse embryonic thymus produces distinct waves
of innate effector γδ T cells. However, it is unclear whether this process occurs similarly in …

Respiratory infectious diseases encountered early in life may result in life-threatening
disease in neonates, which is primarily explained by the relatively naive neonatal immune …

Preterm infants are at high risk of developing neonatal sepsis. γδ T cells are thought to be an
important set of effector cells in neonates. Here, γδ T cells were investigated in a longitudinal …

Vγ9Vδ2 T cells are a major human blood γδ T cell population that respond in a T cell
receptor (TCR)-dependent manner to phosphoantigens which are generated by a variety of …

The complexity of the human immune system is exacerbated by age-related changes to
immune cell functionality. Many of these age-related effects remain undescribed or driven by …

Abstract γδ T cells are increasingly emerging as crucial immune regulators that can take on
innate and adaptive roles in the defence against pathogens. Although they arise within the …

In spite of recent advances in tumour molecular subtyping, pediatric brain tumours (PBTs)
remain the leading cause of cancer-related deaths in children. While some PBTs are …