Synucleinopathies are clinically and pathologically heterogeneous disorders characterized
by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies …

Most neurodegenerative diseases are characterized by the intracellular or extracellular
aggregation of misfolded proteins such as amyloid-β and tau in Alzheimer disease, α …

Growing evidence suggests an increasing significance for the extent of gastrointestinal tract
(GIT) dysfunction in Parkinson's disease (PD). Most patients suffer from GIT symptoms …

The pathway leading from amyloid-β deposition to cognitive impairment is believed to be a
cornerstone of the pathogenesis of Alzheimer's disease (AD). However, what drives amyloid …

Parkinson's disease is a neurological disorder with evolving layers of complexity. It has long
been characterised by the classical motor features of parkinsonism associated with Lewy …

Objective Parkinson's disease (PD) may be caused by an enteric neurotropic pathogen
entering the brain through the vagal nerve, a process that may take over 20 years. We …

Parkinson disease (PD) follows a defined clinical pattern, and a range of nonmotor
symptoms precede the motor phase. The predominant early nonmotor manifestations are …

The progression of many neurodegenerative diseases is thought to be driven by the
template-directed misfolding, seeded aggregation and cell–cell transmission of …

The human microbiota comprises trillions of symbiotic microorganisms and is involved in
regulating gastrointestinal (GI), immune, nervous system and metabolic homeostasis …

Parkinson's disease (PD) is a neurodegenerative disorder for which there is no cure. Most
patients suffer from sporadic PD, which is likely caused by a combination of genetic and …