Pathogenetic mechanisms and treatment targets in cerebral malaria

A Hadjilaou, J Brandi, M Riehn, MA Friese… - Nature Reviews …, 2023 - nature.com
Malaria, the most prevalent mosquito-borne infectious disease worldwide, has accompanied
humanity for millennia and remains an important public health issue despite advances in its …

Therapeutic opportunities of interleukin-33 in the central nervous system

Y Sun, Y Wen, L Wang, L Wen, W You, S Wei… - Frontiers in …, 2021 - frontiersin.org
Interleukin-33 (IL-33), a member of the IL-1 cytokine family, is involved in various diseases.
IL-33 exerts its effects via its heterodimeric receptor complex, which comprises suppression …

Hippocampal interleukin-33 mediates neuroinflammation-induced cognitive impairments

F Reverchon, V De Concini, V Larrigaldie… - Journal of …, 2020 - Springer
Abstract Background Interleukin (IL)-33 is expressed in a healthy brain and plays a pivotal
role in several neuropathologies, as protective or contributing to the development of cerebral …

The potential roles of interleukin-25 in infectious diseases

J Wu, F Zhang, H Tao, W Nawaz, D Chen… - Frontiers in …, 2022 - frontiersin.org
Interleukin-25 (IL-25), also known as IL-17E, is a recently identified cytokine of the IL-17
family. Numerous studies illustrated that the expression of IL-25 is regulated by multiple …

The IL-33/ST2 pathway in cerebral malaria

C Glineur, I Leleu, S Pied - International Journal of Molecular Sciences, 2022 - mdpi.com
Interleukin-33 (IL-33) is an immunomodulatory cytokine which plays critical roles in tissue
function and immune-mediated diseases. IL-33 is abundant within the brain and spinal cord …

The IL-33/ST2 axis in immune responses against parasitic disease: potential therapeutic applications

N Ryan, K Anderson, G Volpedo, S Varikuti… - Frontiers in cellular …, 2020 - frontiersin.org
Parasitic infections pose a wide and varying threat globally, impacting over 25% of the
global population with many more at risk of infection. These infections are comprised of, but …

Critical Roles of IL‐33/ST2 Pathway in Neurological Disorders

MF Abd Rachman Isnadi, VK Chin… - Mediators of …, 2018 - Wiley Online Library
Interleukin‐33 (IL‐33) is an IL‐1 family member, which exhibits both pro‐and anti‐
inflammatory properties solely based on the type of the disease itself. Generally, IL‐33 is …

NK cells contribute to the resolution of experimental malaria-associated acute respiratory distress syndrome after antimalarial treatment

E Pollenus, H Possemiers, S Knoops… - Frontiers in …, 2024 - frontiersin.org
In both humans and mice, natural killer (NK) cells are important lymphocytes of the innate
immune system. They are often considered pro-inflammatory effector cells but may also …

Genetic analysis of cerebral malaria in the mouse model infected with Plasmodium berghei

S Torre, D Langlais, P Gros - Mammalian Genome, 2018 - Springer
Malaria is a common and sometimes fatal disease caused by infection with Plasmodium
parasites. Cerebral malaria (CM) is a most severe complication of infection with Plasmodium …

[HTML][HTML] Interleukin-33 exerts pleiotropic immunoregulatory effects in response to Plasmodium berghei ANKA (PbA) infection in mice

MFAR Isnadi, R Basir, RB Omenesa… - Asian Pacific Journal …, 2023 - journals.lww.com
Objective: To determine the involvement and the modulatory effects of IL-33 during
Plasmodium berghei ANKA (PbA) infection. Methods: PbA infection in male ICR mice was …