The secretion of growth hormone (GH) is regulated through a complex neuroendocrine
control system, especially by the functional interplay of two hypothalamic hypophysiotropic …

There is a large body of evidence that biological aging is related to a series of long-term
catabolic processes resulting in decreased function and structural integrity of several …

Leptin communicates nutritional status to regulatory centers in the brain1, 2. Because
peripheral leptin influences the activity of the highly pulsatile adrenal and gonadal axes3, 4 …

Obesity is associated with insulin resistance and type 2 diabetes; molecular mechanisms
that promote energy expenditure can be utilized for effective therapy. Src-associated in …

Dentate neurogenesis, important for learning and memory, declines dramatically by middle
age. Although studies have shown that this age‐related decrease can be reversed to some …

Research studies clearly indicate that age-related changes in cellular and tissue function
are linked to decreases in the anabolic hormones, growth hormone and insulin-like growth …

N-Methyl-D-aspartate (NMDA) receptors have been reported to have an important role in
synaptic plasticity and neurodegeneration. Two major subtypes of these receptors, NMDAR1 …

Studies in Caenorhabditis elegans demonstrate that disruption of the daf-2 signaling
pathways extends lifespan. Similarities among the daf-2 pathway, insulin-like signaling in …

Life‐history traits describe parameters associated with growth, size, survival, and
reproduction. Life‐history variation is a hallmark of biological diversity, yet researchers …

To define the role of GH during central nervous system development, we performed studies
in cultured rat cerebral cortical cells from 14-(E14) and 17-d-old embryos (E17). The …