Around 3% of the genome consists of simple DNA repeats that are prone to forming
alternative (non-B) DNA structures, such as hairpins, cruciforms, triplexes (H-DNA), four …

With the development and wide usage of CRISPR technology, the presence of R-loop
structures, which consist of an RNA: DNA hybrid and a displaced single strand (ss) DNA …

Simple Summary R-loops are three-stranded structures consisting of an RNA–DNA hybrid
and an unpaired single-stranded DNA (ssDNA), with biological implications in cellular …

Abstract The Repeat Expansion Diseases (REDs) are a large group of human genetic
disorders that result from an increase in the number of repeats in a disease-specific tandem …

Three-stranded DNA: RNA hybrids known as R-loops form when the non-template DNA
strand is displaced and the mRNA transcript anneals to its template strand. Although R-loop …

Autism Spectrum Disorder (ASD) poses significant challenges to society and science due to
its impact on communication, social interaction, and repetitive behavior patterns in affected …

To realize the potential of engineered cells in therapeutic applications, transgenes must be
expressed within the window of therapeutic efficacy. Differences in copy number and other …

The human genome has many short tandem repeats, yet the normal functions of these
repeats are unclear. The 5′ untranslated region (UTR) of the fragile X messenger …

De novo mutations in the RNA binding protein DDX3X cause neurodevelopmental disorders
including DDX3X syndrome and autism spectrum disorder. Amongst~ 200 mutations …

Repeat expansion disorders (REDs) encompass over 50 inherited neurological disorders
and are characterized by the expansion of short tandem nucleotide repeats beyond a …