Oxidative phosphorylation (OXPHOS) occurs through and across the inner mitochondrial
membrane (IMM). Mitochondrial membranes contain a distinct lipid composition, aided by …

Mitochondrial shape and network formation have been primarily associated with the well-
established processes of fission and fusion. However, recent research has unveiled an …

Mitochondria are central for cellular metabolism and energy supply. Barth syndrome (BTHS)
is a severe disorder, due to dysfunction of the mitochondrial cardiolipin acyl transferase …

Barth syndrome (BTHS) is an X-linked mitochondrial lipid disorder caused by mutations in
the TAFAZZIN (TAZ) gene, which encodes a mitochondrial acyltransferase/transacylase …

Barth Syndrome (BTHS) is an inherited cardiomyopathy caused by defects in the
mitochondrial transacylase TAFAZZIN (Taz), required for the synthesis of the phospholipid …

Cardiolipin (CL) is a unique, tetra-acylated diphosphatidylglycerol lipid that mainly localizes
in the inner mitochondria membrane (IMM) in mammalian cells and plays a central role in …

Regulating cardiolipin to maintain mitochondrial homeostasis is a promising strategy for
addressing Parkinson's disease (PD). Through a comprehensive screening and validation …

Mitochondrial cardiomyopathy (MCM) is characterized by abnormal heart-muscle structure
and function, caused by mutations in the nuclear genome or mitochondrial DNA. The …

Mitochondrial phosphatase protein tyrosine phosphatase mitochondrial 1 (Ptpmt1) cKO
(PKO) mice2 provide a model to investigate in vivo mechanisms of MSR in cardiomyocytes …

Mitochondrial dysfunction in heart triggers an integrated stress response (ISR) through
phosphorylation of eIF2α and subsequent ATF4 activation. DAP3 Binding Cell Death …