The development of synthetic methods for the introduction of the fluorine atom and
fluoroalklyl groups into organic molecules has gained increased attention. Synthetic organic …

Fluorinated pyrazoles play an important role in medicinal chemistry, drug discovery,
agrochemistry, coordination chemistry, and organometallic chemistry. Since the early 1990s …

The unique chemistry of small, strained carbocyclic systems has long captivated organic
chemists from a theoretical and fundamental standpoint. A resurgence of interest in strained …

We report the first palladium hydride enabled hydroalkenylation of strained molecules. This
new mild protocol proceeds via a regio-and chemoselective hydropalladation step, followed …

As one of the most powerful trifluoromethylation reagents,(trifluoromethyl) trimethylsilane
(TMSCF3) has been widely used for the synthesis of fluorine-containing molecules …

Fluorine does not belong to the pool of chemical elements that nature uses to build organic
matter. However, chemists have exploited the unique properties of fluorine and produced …

The use of metal catalysts to produce and control the reactivity of carbenes has long offered
a powerful approach to organic synthesis; however, difluorocarbene transfer catalysed by …

1. INTRODUCTION Fluorine is the most abundant halogen in the Earth, s crust. 1 However,
only a dozen fluorinated organic compounds have been identified in nature. 2 Most of the …

Method B 692 3.7. Selective Trifluoromethylation of Multi-Functional Substrates 693 3.8.
Enantioselective Trifluoromethylation 695 3.8. 1. Aldehydes and Ketones: With Cinchona …

This review highlights key reactivities relying on C–C bond cleavages of cyclopropenes.
Metal-catalyzed and metal-free transformations are covered in reactions involving direct ring …