A defining property of cytotoxic lymphocytes is their expression and regulated secretion of
potent toxins, including the pore-forming protein perforin and serine protease granzymes …

Pore-forming toxins (PFTs) are virulence factors produced by many pathogenic bacteria and
have long fascinated structural biologists, microbiologists and immunologists. Interestingly …

Extracellular vesicles (EVs) deliver bioactive macromolecules (ie proteins, lipids and nucleic
acids) for intercellular communication in multicellular organisms. EVs are secreted by all cell …

Membrane attack complex/perforin/cholesterol-dependent cytolysin (MACPF/CDC) proteins
constitute a major superfamily of pore-forming proteins that act as bacterial virulence factors …

Pore-forming toxins (PFTs) are widely distributed in both Gram-negative and Gram-positive
bacteria. PFTs can act as virulence factors that bacteria utilise in dissemination and host …

The membrane attack complex (MAC)/perforin-like protein complement component 9 (C9) is
the major component of the MAC, a multi-protein complex that forms pores in the membrane …

The mechanism by which the cholesterol-dependent cytolysins (CDCs) assemble their giant
β-barrel pore in cholesterol-rich membranes has been the subject of intense study in the …

The cholesterol-dependent cytolysins (CDCs) are a family of bacterial protein toxins
specifically targeting eukaryotic cells through the absolute requirement for high …

Abstract Pore Forming Toxins (PFTs) represent a key mechanism for permitting the passage
of proteins and small molecules across the lipid membrane. These proteins are typically …

The cholesterol-dependent cytolysins (CDCs) are a family of bacterial toxins that are
important virulence factors for a number of pathogenic Gram-positive bacterial species …