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The practice of xenotransplantation using pig islet cells or organs is under development to
alleviate the shortage of human donor islet cells or organs for the treatment of diabetes or …

Background Genetically engineered pigs could provide a source of kidneys for clinical
transplantation. The two longest kidney graft survivals reported to date have been 136 and …

Xenotransplantation has the potential to alleviate the organ shortage that prevents many
patients with end‐stage renal disease from enjoying the benefits of kidney transplantation …

Porcine endogenous retroviruses (PERVs) are integrated in the genome of all pigs, and
some of them are able to infect human cells. Therefore, PERVs pose a risk for …

Porcine cytomegalovirus (PCMV), that is actually a porcine roseolovirus (PRV), is a common
herpesvirus in domestic pigs and wild boars. In xenotransplantation, PCMV/PRV has been …

Xenotransplantation using pig organs has achieved survival times up to 195 days in pig
orthotopic heart transplantation into baboons. Here we demonstrate that in addition to an …

The immunologic barriers to successful xenotransplantation are related to the presence of
natural anti‐pig antibodies in humans and non‐human primates that bind to antigens …

This guidance was developed to summarize current approaches to the potential
transmission of swine-derived organisms to xenograft recipients, health care providers, or …

The clinical course of the first patient to receive a gene‐edited pig heart transplant was
recently reported by the University of Maryland team. Although the pig heart functioned well …