In the recent years, a paradigm shift is taking place where metallic/synthetic implants and
tissue grafts are being replaced by tissue engineering approach. A well designed three …

Osteogenesis is the process of new bone formation where transcription factors play an
important role in controlling cell proliferation and differentiation. Runt-related transcription …

Syringic acid (SA) is a natural phenolic acid found in vegetables, fruits, and other plant-
based foods. A range of biological activities were proposed for this compound including …

Abstract The presence of Reactive Oxygen Species (ROS) in bone can influence resident
cells behaviour as well as the extra-cellular matrix composition and the tissue architecture …

Cucurbita moschata Duchesne (Cucurbitaceae) is a plant food highly appreciated for the
content of nutrients and bioactive compounds, including polyphenols and carotenoids …

Hundreds of millions of people are influenced by neurodegenerative disorders such as
Alzheimer's disease (AD) and Parkinson's disease (PD), traumatic disorders of the nervous …

Polyphenols are a large family of more than 10,000 naturally occurring compounds, which
exert countless pharmacological, biological and physiological benefits for human health …

MicroRNA (miRNA) has shown to enhance or inhibit cell proliferation, differentiation and
activity of different cell types in bone tissue. The discovery of miRNA actions and their targets …

Bone is a highly integrative and dynamic tissue of the human body that is regularly modeled
and remodeled by bone cells such as osteoblasts and osteoclasts. When a fraction of a …

Bone is a highly vascularized tissue that relies on a close spatial and temporal interaction
between blood vessels and bone cells. As a result, angiogenesis is critical for bone …