The exposure of the skin to medical drugs, skin care products, cosmetics, and other
chemicals renders information on xenobiotic-metabolizing enzymes (XME) in the skin highly …

The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that
regulates the transcription of certain key enzymes involved in the metabolism of xenobiotic …

We have evaluated the performance characteristics of three quantitative gene expression
technologies and correlated their expression measurements to those of five commercial …

The goal of this review is to stress the importance of the cytochrome P450 (CYP) superfamily
that is expressed in human skin in the hope that it may stimulate further study in an intriguing …

Cytochrome P450 (CYP) 1B1 is overexpressed in tumor cells and is also recognized as a
biomarker of the tumor phenotype. This review highlights the tremendous potential of this …

Studies on the metabolic fate of medical drugs, skin care products, cosmetics and other
chemicals intentionally or accidently applied to the human skin have become increasingly …

A distinction is made between viability, metabolic toxicity, and cell survival assays and the
implications of each for the design of assays. Protocols are provided for measuring viability …

The soil nematode Caenorhabditis elegans is frequently used in ecotoxicological studies
due to its wide distribution in terrestrial habitats, its easy handling in the laboratory, and its …

Smoking has been associated with diseases of the lung, pulmonary airways and oral cavity.
Cytologic, genomic and transcriptomic changes in oral mucosa correlate with oral pre …

During half a century, cytochrome P450 in its original uniqueness as an optically" wrong"
cytochrome has attracted many investigators, who have contributed to the unveiling of a …