Immune regulatory networks coordinated by glycans and glycan-binding proteins in autoimmunity and infection

SS Pinho, I Alves, J Gaifem… - Cellular & Molecular …, 2023 - nature.com
The immune system is coordinated by an intricate network of stimulatory and inhibitory
circuits that regulate host responses against endogenous and exogenous insults. Disruption …

The benefits and pitfalls of machine learning for biomarker discovery

S Ng, S Masarone, D Watson, MR Barnes - Cell and Tissue Research, 2023 - Springer
Prospects for the discovery of robust and reproducible biomarkers have improved
considerably with the development of sensitive omics platforms that can enable …

A unique serum IgG glycosylation signature predicts development of Crohn's disease and is associated with pathogenic antibodies to mannose glycan

J Gaifem, CS Rodrigues, F Petralia, I Alves… - Nature …, 2024 - nature.com
Inflammatory bowel disease (IBD) is characterized by chronic inflammation in the gut. There
is growing evidence in Crohn's disease (CD) of the existence of a preclinical period …

[HTML][HTML] The role of glycans in health and disease: Regulators of the interaction between gut microbiota and host immune system

LI Crouch, CS Rodrigues, CR Bakshani… - Seminars in …, 2024 - Elsevier
The human gut microbiota is home to a diverse collection of microorganisms that has co-
evolved with the host immune system in which host-microbiota interactions are essential to …

Glycovaccinology: The design and engineering of carbohydrate-based vaccine components

SW Hulbert, P Desai, MC Jewett, MP DeLisa… - Biotechnology …, 2023 - Elsevier
Vaccines remain one of the most important pillars in preventative medicine, providing
protection against a wide array of diseases by inducing humoral and/or cellular immunity. Of …

Host-derived mannose glycans trigger a pathogenic γδ T cell/IL-17a axis in autoimmunity

I Alves, B Santos-Pereira, N de la Cruz… - Science Translational …, 2023 - science.org
Autoimmune diseases are life-threatening disorders that cause increasing disability over
time. Systemic lupus erythematosus (SLE) and other autoimmune diseases arise when …

Structural characterization and immune activity evaluation of a polysaccharide from Lyophyllum Decastes

XJ Li, SJ Xiao, YH Xie, J Chen, HR Xu, Y Yin… - International Journal of …, 2024 - Elsevier
An innovative acidic hydrolysate fingerprinting workflow was proposed for the
characterization of Lyophyllum Decastes polysaccharide (LDP) by ultra performance liquid …

Glycan Shape, Motions, and Interactions Explored by NMR Spectroscopy

G Widmalm - JACS Au, 2024 - ACS Publications
Glycans in the form of oligosaccharides, polysaccharides, and glycoconjugates are
ubiquitous in nature, and their structures range from linear assemblies to highly branched …

The blessed union of glycobiology and immunology: a marriage that worked

JS Dos Reis, I Diniz-Lima, MARC Santos, PM Barcelos… - Medicines, 2023 - mdpi.com
In this article, we discuss the main aspects regarding the recognition of cell surface
glycoconjugates and the immunomodulation of responses against the progression of certain …

Glycobiology of rheumatic diseases

T Kissel, REM Toes, TWJ Huizinga… - Nature Reviews …, 2023 - nature.com
Glycosylation has a profound influence on protein activity and cell biology through a variety
of mechanisms, such as protein stability, receptor interactions and signal transduction. In …