[HTML][HTML] The structure and regulation of magnesium selective ion channels
J Payandeh, R Pfoh, EF Pai - Biochimica et Biophysica Acta (BBA) …, 2013 - Elsevier
Abstract The magnesium ion (Mg 2+) is the most abundant divalent cation within cells. In
man, Mg 2+-deficiency is associated with diseases affecting the heart, muscle, bone …
man, Mg 2+-deficiency is associated with diseases affecting the heart, muscle, bone …
Molecular basis of Mg2+ permeation through the human mitochondrial Mrs2 channel
M Li, Y Li, Y Lu, J Li, X Lu, Y Ren, T Wen… - Nature …, 2023 - nature.com
Abstract Mitochondrial RNA splicing 2 (Mrs2), a eukaryotic CorA ortholog, enables Mg2+ to
permeate the inner mitochondrial membrane and plays an important role in mitochondrial …
permeate the inner mitochondrial membrane and plays an important role in mitochondrial …
Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation
The CorA family of proteins regulates the homeostasis of divalent metal ions in many
bacteria, archaea, and eukaryotic mitochondria, making it an important target in the …
bacteria, archaea, and eukaryotic mitochondria, making it an important target in the …
Amphipathic lipid packing sensor motifs: probing bilayer defects with hydrophobic residues
Sensing membrane curvature allows fine-tuning of complex reactions that occur at the
surface of membrane-bound organelles. One of the most sensitive membrane curvature …
surface of membrane-bound organelles. One of the most sensitive membrane curvature …
Sitting at the edge: How biomolecules use hydrophobicity to tune their interactions and function
Water near extended hydrophobic surfaces is like that at a liquid–vapor interface, where
fluctuations in water density are substantially enhanced compared to those in bulk water …
fluctuations in water density are substantially enhanced compared to those in bulk water …
Molecular dynamics simulations of phosphatidylcholine membranes: a comparative force field study
Molecular dynamics simulations provide a route to studying the dynamics of lipid bilayers at
atomistic or near atomistic resolution. Over the past 10 years or so, molecular dynamics …
atomistic or near atomistic resolution. Over the past 10 years or so, molecular dynamics …
Conical lipids in flat bilayers induce packing defects similar to that induced by positive curvature
In biological membranes, changes in lipid composition or mechanical deformations produce
defects in the geometrical arrangement of lipids, thus allowing the adsorption of certain …
defects in the geometrical arrangement of lipids, thus allowing the adsorption of certain …
Cryo-EM structures of human magnesium channel MRS2 reveal gating and regulatory mechanisms
Abstract Magnesium ions (Mg2+) play an essential role in cellular physiology. In
mitochondria, protein and ATP synthesis and various metabolic pathways are directly …
mitochondria, protein and ATP synthesis and various metabolic pathways are directly …
Automated cryo-EM structure refinement using correlation-driven molecular dynamics
We present a correlation-driven molecular dynamics (CDMD) method for automated
refinement of atomistic models into cryo-electron microscopy (cryo-EM) maps at resolutions …
refinement of atomistic models into cryo-electron microscopy (cryo-EM) maps at resolutions …
Statistical convergence of equilibrium properties in simulations of molecular solutes embedded in lipid bilayers
In recent years, atomistic molecular simulations have become a method of choice for
studying the interaction of small molecules, peptides, and proteins with biological …
studying the interaction of small molecules, peptides, and proteins with biological …