Abstract Moorman, Antoon FM, and Vincent M. Christoffels. Cardiac Chamber Formation:
Development, Genes, and Evolution. Physiol Rev 83: 1223-1267, 2003; 10.1152/physrev …

The mammalian heart is the first functional organ, the first indicator of life. Its normal
formation and function are essential for fetal life. Defects in heart formation lead to …

The mammalian heart undergoes maturation during postnatal life to meet the increased
functional requirements of an adult. However, the key drivers of this process remain poorly …

Heterozygous Tbx5 del/+ mice were generated to study the mechanisms by which TBX5
haploinsufficiency causes cardiac and forelimb abnormalities seen in Holt-Oram syndrome …

The heart develops from two bilateral heart fields that are formed during early gastrulation. In
recent years, signaling pathways that specify cardiac mesoderm have been extensively …

Cardiac fibrosis is a common feature of chronic heart failure. Iroquois homeobox (IRX) family
of transcription factors plays important roles in heart development; however, the role of IRX2 …

Mature mammary epithelial cells are generated from undifferentiated precursors through a
hierarchical process, but the molecular mechanisms involved, particularly in the human …

The heart is the first organ to form during embryogenesis and its circulatory function is critical
from early on for the viability of the mammalian embryo. Developmental abnormalities of the …

Transcription factors can regulate the expression of other genes in a tissue-specific and
quantitative manner and are thus major regulators of embryonic developmental processes …

During the past two decades, numerous disease-causing genes for different
cardiomyopathies have been identified. These discoveries have led to better understanding …