Klebsiella pneumoniae causes a wide range of infections, including pneumonias, urinary
tract infections, bacteremias, and liver abscesses. Historically, K. pneumoniae has caused …

Acute pancreatitis may be associated with both local and systemic complications. Systemic
injury manifests in the form of organ failure, which is seen in approximately 20% of all cases …

Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play
important roles in immunity, cell growth, and cell signaling. In excess, however, ROS are …

Hepatocytes, the major parenchymal cells in the liver, play pivotal roles in metabolism,
detoxification, and protein synthesis. Hepatocytes also activate innate immunity against …

The acute respiratory distress syndrome (ARDS) is a life-threatening lung condition resulting
from direct and indirect insults to the lung. It is characterized by disruption of the endothelial …

Neutrophils play a pivotal role in the innate immune response. The small cytokine CXCL8
(also known as IL-8) is known to be one of the most potent chemoattractant molecules that …

Successful host defense against numerous pulmonary infections depends on bacterial
clearance by polymorphonuclear leukocytes (PMNs); however, excessive PMN …

Background and aims Peripancreatic fat necrosis occurs frequently in necrotising
pancreatitis. Distinguishing markers from mediators of severe acute pancreatitis (SAP) is …

The rise of multidrug-resistant pathogens and the dearth of new antibiotic development
place an existential strain on successful infectious disease therapy. Breakthrough strategies …

Klebsiella pneumoniae is a common respiratory pathogen, with some strains having
developed broad resistance to clinically available antibiotics. Humans can become infected …