Though many folded proteins assume one stable structure that performs one function, a
small‐but‐increasing number remodel their secondary and tertiary structures and change …

Metamorphic proteins are single amino acid sequences that reversibly interconvert between
multiple, dramatically different native structures, often with distinct functions. Since the …

The ORF9b protein, derived from the nucleocapsid's open-reading frame in both SARS-CoV
and SARS-CoV-2, serves as an accessory protein crucial for viral immune evasion by …

SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is the causative agent of
the COVID19 pandemic. The SARS-CoV-2 genome encodes for a small accessory protein …

The emergence of the COVID-19 pandemic, caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), remains a great threat to global health. ORF9b, an important …

Fold‐switching proteins, which remodel their secondary and tertiary structures in response
to cellular stimuli, suggest a new view of protein fold space. For decades, experimental …

The COVID-19 pandemic has been driven by the emergence of SARS-CoV-2 variants with
mutations across all the viral proteins. Although mutations in the spike protein have received …

Metamorphic proteins constitute unexpected paradigms of the protein folding problem, as
their sequences encode two alternative folds, which reversibly interconvert within …

Extant fold‐switching proteins remodel their secondary structures and change their functions
in response to cellular stimuli, regulating biological processes and affecting human health …

In classical amyloidoses, amyloid fibres form through the nucleation and accretion of protein
monomers, with protofibrils and fibrils exhibiting a cross-β motif of parallel or antiparallel β …