The structural investigation of amorphous pharmaceuticals is of paramount importance in
comprehending their physicochemical stability. However, it has remained a relatively …

Raman spectroscopy (RS) is a nondestructive analytical method extensively utilized in the
field of biomedical, and pharmaceutical applications due to their high sensitivity …

Transmission Raman spectroscopy (TRS) is a process analytical technology tool for
nondestructive analysis of drug content in tablets. Although wet granulation is the most used …

Magnesium stearate (MgSt) is perhaps one of the most frequently used lubricants in tablet
formulation due to its superior lubrication capacity, yet it could also negatively affect the …

Purpose Using a high level of mannitol as a diluent in oral formulations can potentially result
in tablet defects (eg, chipping, cracking) during compression. This work aims to scrutinize …

An in situ Raman method was developed to characterize the disproportionation of two salts
involving a complex polymorphic landscape comprising up to two metastable and one stable …

For liquid drug products, eg, solutions or suspensions for oral or parenteral dosing, stability
needs to be demonstrated in primary packaging during storage and in dosing devices …

Water is omnipresent during pharmaceutical product manufacturing and may interact with
the drug substance, excipients, and the drug product in either solvent or vapor form …