Cognitive deficit in schizophrenia: from etiology to novel treatments

AL Martínez, J Brea, S Rico, MT De los Frailes… - International journal of …, 2021 - mdpi.com
Schizophrenia is a major mental illness characterized by positive and negative symptoms,
and by cognitive deficit. Although cognitive impairment is disabling for patients, it has been …

Central nervous system effects of 5-HT7 receptors: a potential target for neurodegenerative diseases

A Quintero-Villegas, SI Valdés-Ferrer - Molecular Medicine, 2022 - Springer
HT7 receptors (5-HT7R) are the most recently identified among the family of serotonin
receptors. Their role in health and disease, particularly as mediators of, and druggable …

Transcranial ultrasound neuromodulation facilitates isoflurane-induced general anesthesia recovery and improves cognition in mice

J He, Y Zhu, C Wu, J Wu, Y Chen, M Yuan, Z Cheng… - Ultrasonics, 2023 - Elsevier
Delayed arousal and cognitive dysfunction are common, especially in older patients after
general anesthesia (GA). Elevating central nervous system serotonin (5-HT) levels can …

[HTML][HTML] Synthesis, computational and experimental pharmacological studies for (thio) ether-triazine 5-HT6R ligands with noticeable action on AChE/BChE and …

K Czarnota-Łydka, S Sudoł-Tałaj… - European Journal of …, 2023 - Elsevier
Alzheimer's disease is becoming a growing problem increasing at a tremendous rate.
Serotonin 5-HT 6 receptors appear to be a particularly attractive target from a therapeutic …

Neuromodulators and long-term synaptic plasticity in learning and memory: A steered-glutamatergic perspective

AH Bazzari, HR Parri - Brain sciences, 2019 - mdpi.com
The molecular pathways underlying the induction and maintenance of long-term synaptic
plasticity have been extensively investigated revealing various mechanisms by which …

Role of the serotonin receptor 7 in brain plasticity: From development to disease

M Crispino, F Volpicelli, C Perrone-Capano - International journal of …, 2020 - mdpi.com
Our knowledge on the plastic functions of the serotonin (5-HT) receptor subtype 7 (5-HT7R)
in the brain physiology and pathology have advanced considerably in recent years. A wealth …

Therapeutic potential and limitation of serotonin type 7 receptor modulation

K Fukuyama, E Motomura, M Okada - International Journal of Molecular …, 2023 - mdpi.com
Although a number of mood-stabilising atypical antipsychotics and antidepressants
modulate serotonin type 7 receptor (5-HT7), the detailed contributions of 5-HT7 function to …

Current limitations and candidate potential of 5-HT7 receptor antagonism in psychiatric pharmacotherapy

R Okubo, T Hasegawa, K Fukuyama… - Frontiers in …, 2021 - frontiersin.org
Several mood-stabilizing atypical antipsychotics and antidepressants weakly block
serotonin (5-HT) receptor type-7 (5-HT7R); however, the contributions of 5-HT7R …

New trends in the treatment of schizophrenia

HY Meltzer - CNS & Neurological Disorders-Drug Targets …, 2017 - ingentaconnect.com
Objectives: This article are to describe current trends in the treatment of schizophrenia and
the most interesting new approaches to optimizing outcome and fostering the development …

Effects of subchronic administrations of vortioxetine, lurasidone, and escitalopram on thalamocortical glutamatergic transmission associated with serotonin 5-ht7 …

M Okada, R Matsumoto, Y Yamamoto… - International journal of …, 2021 - mdpi.com
The functional suppression of serotonin (5-HT) type 7 receptor (5-HT7R) is forming a basis
for scientific discussion in psychopharmacology due to its rapid-acting antidepressant-like …