Single-cell investigation of lead toxicity from neurodevelopment to neurodegeneration: Current review and future opportunities

MM Sampson, RK Morgan, SA Sloan… - Current Opinion in …, 2024 - Elsevier
Human exposure to the metal lead (Pb) is prevalent and associated with adverse
neurodevelopmental and neurodegenerative outcomes. Pb disrupts normal brain function …

Sex and tissue-specificity of piRNA regulation in adult mice following perinatal lead (Pb) exposure

BPU Perera, K Wang, D Wang, K Chen, A Dewald… - Epigenetics, 2024 - Taylor & Francis
Lead (Pb) is a neurotoxicant with early life exposure linked to long-term health effects. Piwi-
interacting RNAs (piRNAs) are small non-coding RNAs that associate with PIWIL proteins to …

Sex-Specific Deflection of Age-Related DNA Methylation and Gene Expression in Mouse Heart by Perinatal Toxicant Exposures

K Wang, MA Sartor, JA Colacino, DC Dolinoy… - bioRxiv, 2024 - biorxiv.org
Background: Global and site-specific changes in DNA methylation and gene expression are
associated with cardiovascular aging and disease, but how toxicant exposures during early …