Targeting SARS-CoV-2 entry processes: The promising potential and future of host-targeted small-molecule inhibitors
A Wu, K Shi, J Wang, R Zhang, Y Wang - European Journal of Medicinal …, 2024 - Elsevier
The COVID-19 pandemic, caused by SARS-CoV-2, has had a huge impact on global health.
To respond to rapidly mutating viruses and to prepare for the next pandemic, there is an …
To respond to rapidly mutating viruses and to prepare for the next pandemic, there is an …
Plexin structures are coming: opportunities for multilevel investigations of semaphorin guidance receptors, their cell signaling mechanisms, and functions
Plexin transmembrane receptors and their semaphorin ligands, as well as their co-receptors
(Neuropilin, Integrin, VEGFR2, ErbB2, and Met kinase) are emerging as key regulatory …
(Neuropilin, Integrin, VEGFR2, ErbB2, and Met kinase) are emerging as key regulatory …
Novel small-molecule inhibitors of the SARS-CoV-2 spike protein binding to neuropilin 1
A Kolarič, M Jukič, U Bren - Pharmaceuticals, 2022 - mdpi.com
Furin cleavage of the SARS-CoV-2 spike protein results in a polybasic terminal sequence
termed the C-end rule (CendR), which is responsible for the binding to neuropilin 1 (NRP1) …
termed the C-end rule (CendR), which is responsible for the binding to neuropilin 1 (NRP1) …
Novel compounds targeting neuropilin receptor 1 with potential to interfere with SARS-CoV-2 virus entry
Neuropilin-1 (NRP-1) is a multifunctional transmembrane receptor for ligands that affect
developmental axonal growth and angiogenesis. In addition to a role in cancer, NRP-1 is a …
developmental axonal growth and angiogenesis. In addition to a role in cancer, NRP-1 is a …
Neuropilin (NRPs) related pathological conditions and their modulators
M Broz, A Kolarič, M Jukič, U Bren - International journal of molecular …, 2022 - mdpi.com
Neuropilin 1 (NRP1) represents one of the two homologous neuropilins (NRP, splice
variants of neuropilin 2 are the other) found in all vertebrates. It forms a transmembrane …
variants of neuropilin 2 are the other) found in all vertebrates. It forms a transmembrane …
Targeting VEGF–neuropilin interactions: A promising antitumor strategy
K Peng, Y Bai, Q Zhu, B Hu, Y Xu - Drug discovery today, 2019 - Elsevier
Highlights•Neuropilins (NRP) have been identified as essential coreceptors for vascular
endothelial growth factors (VEGF).•VEGF-NRP interactions exert multifaceted effects on …
endothelial growth factors (VEGF).•VEGF-NRP interactions exert multifaceted effects on …
Structure-based discovery of a small non-peptidic Neuropilins antagonist exerting in vitro and in vivo anti-tumor activity on breast cancer model
L Borriello, M Montès, Y Lepelletier, B Leforban… - Cancer letters, 2014 - Elsevier
Abstract Neuropilin-1/-2 (+ 33 NRPs), VEGF-A 165 co-receptors, are over-expressed during
cancer progression. Thus, NRPs targeted drug development is challenged using a multistep …
cancer progression. Thus, NRPs targeted drug development is challenged using a multistep …
NRPa-308, a new neuropilin-1 antagonist, exerts in vitro anti-angiogenic and anti-proliferative effects and in vivo anti-cancer effects in a mouse xenograft model
Abstract Neuropilin-1 (NRP-1) is an extra-cellular receptor for the main Vascular Endothelial
Growth Factor over-expressed in tumour tissues, VEGF-A 165. Consequently, NRP-1 is …
Growth Factor over-expressed in tumour tissues, VEGF-A 165. Consequently, NRP-1 is …
[HTML][HTML] In silico identification and validation of inhibitors of the interaction between neuropilin receptor 1 and SARS-CoV-2 Spike protein
Abstract Neuropilin-1 (NRP-1) is a multifunctional transmembrane receptor for ligands that
affect developmental axonal growth and angiogenesis. In addition to a role in cancer, NRP-1 …
affect developmental axonal growth and angiogenesis. In addition to a role in cancer, NRP-1 …
Carbohydrate-based peptidomimetics targeting neuropilin-1: Synthesis, molecular docking study and in vitro biological activities
M Richard, A Chateau, C Jelsch, C Didierjean… - Bioorganic & Medicinal …, 2016 - Elsevier
Abstract Neuropilin-1 (NRP-1), a transmembrane glycoprotein acting as a co-receptor of
VEGF-A, is expressed by cancer and angiogenic endothelial cells and is involved in the …
VEGF-A, is expressed by cancer and angiogenic endothelial cells and is involved in the …