Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA

P Gao, YQ Liu, W Xiao, F Xia, JY Chen, LW Gu… - Military Medical …, 2022 - Springer
Background Malaria is a devastating infectious disease that disproportionally threatens
hundreds of millions of people in developing countries. In the history of anti-malaria …

Physical chemistry of chloroquine permeation through the cell membrane with atomistic detail

M Paulikat, GM Piccini, E Ippoliti… - Journal of Chemical …, 2023 - ACS Publications
We provide a molecular-level description of the thermodynamics and mechanistic aspects of
drug permeation through the cell membrane. As a case study, we considered the antimalaria …

[图书][B] Biophysical and Computational Tools in Drug Discovery

AK Saxena - 2021 - Springer
The global pharma industry is facing new challenges due to generic competition, patent
expirations, and lack of innovations. Hence, the adaptation of innovative and cost-effective …

Identification of 5‐(3‐(methylsulfonyl)phenyl)‐3‐(4‐(methylsulfonyl)phenyl)‐3H‐imidazo[4,5‐b]pyridine as novel orally bioavailable and metabolically stable …

M Kundu, A Dutta, KK Roy, SK Mal… - Chemical Biology & …, 2023 - Wiley Online Library
Malaria continues to be a significant public health problem threatened by the emergence
and spread of resistance to artemisinin‐based combination therapies and marked half a …

Physical Chemistry of Drug Permeation through the Cell Membrane with Atomistic Detail

M Paulikat, GM Piccini, E Ippoliti, G Rossetti… - bioRxiv, 2023 - biorxiv.org
We provide a molecular-level description of the thermodynamics and mechanistic aspects of
drug permeation through the cell membrane. As a case study, we considered the anti …

Probing with Pharmacophore Modeling the Chloroquine Resistance and Designing Novel Antimalarials

P Kumar, I Ghosh - Biophysical and Computational Tools in Drug …, 2021 - Springer
Needless to say that cure from malaria disease is a longstanding goal and helping the
present worldwide effort to reduce the malarial disease burden by many folds. Chloroquine …

Identification and characterization of novel chemical scaffolds to overcome drug resistance in malaria

DWJ Tay - 2020 - dr.ntu.edu.sg
Till today, malaria remains one of the most prominent infectious diseases in the world. Since
the beginning of the decade, the number of malaria cases has drastically decreased, in no …

Transforming the CRISPR/dCas9-based gene regulation technique into a forward screening tool in Plasmodium falciparum

AB Lucky, C Wang, X Li, X Liang, A Muneer, J Miao - Iscience, 2024 - cell.com
It is a significant challenge to assess the functions of many uncharacterized genes in human
malaria parasites. Here, we present a genetic screening tool to assess the contribution of …