In the past few decades, the field of neuroepigenetics has investigated how the brain
encodes information to form long-lasting memories that lead to stable changes in behaviour …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

Abstract Background Nuclear acetyl-CoA pools govern histone acetylation that controls
synaptic plasticity and contributes to cognitive deterioration in patients with Alzheimer's …

Substance use disorders (SUDs) are highly prevalent. SUDs involve vicious cycles of binges
followed by occasional periods of abstinence with recurrent relapses despite treatment and …

Drug addiction involves long-term behavioral abnormalities that arise in response to
repeated exposure to drugs of abuse in vulnerable individuals. It is a multifactorial syndrome …

Rationale and objectives Addiction to psychostimulant methamphetamine (METH) remains a
major public health problem in the world. Animal models that use METH self-administration …

Methamphetamine is a widely abused drug, which possesses neurotoxic activity and
powerful addictive effects. Understanding methamphetamine toxicity is key beyond the field …

Amphetamine and methamphetamine addiction is described by specific behavioral
alterations, suggesting long-lasting changes in gene and protein expression within specific …

Astrocytes provide support for neurons, regulate metabolic processes, and influence
neuronal communication in a variety of ways, including through the homeostatic regulation …

Background The incubation of cue-induced drug craving in rodents provides a model of
persistent vulnerability to craving and relapse in human addicts. After prolonged withdrawal …