RNA-based therapies have catalyzed a revolutionary transformation in the biomedical
landscape, offering unprecedented potential in disease prevention and treatment. However …

The RASopathies are a group of clinically defined developmental syndromes caused by
germline variants of the RAS/mitogen‐activated protein (MAPK) cascade. The prototypic …

Biologics, including proteins and antisense oligonucleotides (ASOs), face significant
challenges when it comes to achieving intracellular delivery within specific organs or cells …

Aptamers face challenges for use outside the ideal conditions in which they are developed.
These difficulties are most palpable in vivo due to nuclease activities, rapid clearance, and …

Non-small-cell lung cancer (NSCLC) is the second most diagnosed type of malignancy and
the first cause of cancer death worldwide. Despite recent advances, the treatment of choice …

Pulmonary drug delivery is critical for the treatment of respiratory diseases. However, the
human airway surface presents multiple barriers to efficient drug delivery. Here, we report a …

Functional nucleic acids (FNAs) have attracted increasing attention in recent years due to
their diverse physiological functions. The understanding of their conformational recognition …

Oligonucleotide therapeutics have the unique ability to address traditionally undruggable
targets through various target engagement pathways. However, despite advances in …

Cationic polymers used for nucleic acid delivery often suffer from complicated syntheses,
undesired intracellular cargo release and low serum stability. Herein, a series of ternary …

We have developed a non-cationic transfection vector in the form of bottlebrush polymer-
antisense oligonucleotide (ASO) conjugates. Termed pacDNA (polymer-assisted …