Infertility affects~ 7% of couples of reproductive age with little change in incidence in the last
two decades. ART, as well as other interventions, have made major strides in correcting this …

It has become a current social trend for women to delay childbearing. However, the quality of
oocytes from older females is compromised and the pregnancy rate of older women is lower …

Age-related accumulation of ploidy changes is associated with decreased expression of
genes controlling chromosome segregation and cohesin functions. To determine the …

Chromosome segregation errors during female meiosis are a leading cause of pregnancy
loss and human infertility. The segregation of chromosomes is driven by interactions …

In their midthirties, women experience a decline in fertility, coupled to a pronounced
increase in the risk of aneuploidy, miscarriage, and birth defects. Although the aetiology of …

Alterations in the oocyte's environment can negatively affect embryo development. Oocyte
quality, which can determine embryonic viability, is easily perturbed, thus factors affecting …

STUDY QUESTION Is the postovulatory aging-dependent differential decrease of mRNAs
and polyadenylation of mRNAs coded by maternal effect genes associated with altered …

Early mouse embryos have an atypical translational machinery that consists of cytoplasmic
lattices and is poorly competent for translation. Hence, the impact of transcriptomic changes …

Aging has many effects on the female reproductive system, among which decreased oocyte
quality and impaired embryo developmental potential are the most important factors …

Aneuploidy and polyploidy are a form of Genomic Instability (GIN) known as Chromosomal
Instability (CIN) characterized by sporadic abnormalities in chromosome copy numbers …