Breast cancer management has progressed immensely over the decades, but the disease is
still a major source of morbidity and mortality worldwide. Even with enhanced imaging …

Progranulin (Pgrn) is a pluripotent secreted growth factor that mediates cell cycle
progression and cell motility. It activates the extracellular regulated kinases and …

Increased leukocyte elastase activity in mice lacking secretory leukocyte protease inhibitor
(SLPI) leads to impaired wound healing due to enhanced activity of TGFβ and perhaps …

Abstract Annually, 1.25 million individuals suffer burns in the United States and 6.5 million
experience chronic skin ulcers, often from diabetes, pressure or venous stasis. Growth …

Recently, mutations in the progranulin (PGRN) gene were found to cause familial and
apparently sporadic frontotemporal lobe dementia (FTLD). Moreover, missense changes in …

The growth factor progranulin (PGRN) regulates cell division, survival, and migration. PGRN
is an extracellular glycoprotein bearing multiple copies of the cysteine‐rich granulin motif …

Granulins, also called epithelins, are 6-kD peptides with growth modulatory effects on a
variety of cells. The granulin/epithelin precursor supports tumorigenesis in appropriate cell …

Review on the role of progranulin in immunity, infection, and inflammation, and its
therapeutic potential in treating inflammatory conditions. PGRN, a pleiotrophic growth factor …

Signal transducers and activators of transcription (STATs) mediate essential signaling
pathways in different biological processes, including immune responses, hematopoiesis …

Progranulin, a secreted glycoprotein, is encoded in humans by the single GRN gene.
Progranulin consists of seven and a half, tandemly repeated, non-identical copies of the 12 …