A review of the common neurodegenerative disorders: current therapeutic approaches and the potential role of nanotherapeutics

RNL Lamptey, B Chaulagain, R Trivedi… - International journal of …, 2022 - mdpi.com
Neurodegenerative disorders are primarily characterized by neuron loss. The most common
neurodegenerative disorders include Alzheimer's and Parkinson's disease. Although there …

Oxidative stress and regulated cell death in Parkinson's disease

PA Dionísio, JD Amaral, CMP Rodrigues - Ageing research reviews, 2021 - Elsevier
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide. Motor deficits usually associated with PD correlate with dopaminergic axonal …

Signaling pathways in Parkinson's disease: molecular mechanisms and therapeutic interventions

X Dong-Chen, C Yong, X Yang, ST Chen-Yu… - Signal transduction and …, 2023 - nature.com
Parkinson's disease (PD) is the second most common neurodegenerative disease
worldwide, and its treatment remains a big challenge. The pathogenesis of PD may be …

[HTML][HTML] Transneuronal propagation of pathologic α-synuclein from the gut to the brain models Parkinson's disease

S Kim, SH Kwon, TI Kam, N Panicker… - Neuron, 2019 - cell.com
Analysis of human pathology led Braak to postulate that α-synuclein (α-syn) pathology could
spread from the gut to brain via the vagus nerve. Here, we test this postulate by assessing α …

Parkinson's disease: etiology, neuropathology, and pathogenesis

A Kouli, KM Torsney, WL Kuan - Exon Publications, 2018 - exonpublications.com
Parkinson's disease (PD) is a common neurodegenerative disorder. While a number of
nonmotor manifestations arise, the typical clinical features involve a movement disorder …

Parkinson's disease: Mechanisms, translational models and management strategies

C Raza, R Anjum - Life sciences, 2019 - Elsevier
Parkinson's disease is a progressive neurodegenerative disorder. The classical motor
symptoms include resting tremors, bradykinesia, rigidity and postural instability and are …

An explainable machine learning model for early detection of Parkinson's disease using LIME on DaTSCAN imagery

PR Magesh, RD Myloth, RJ Tom - Computers in Biology and Medicine, 2020 - Elsevier
Parkinson's Disease (PD) is a degenerative and progressive neurological condition. Early
diagnosis can improve treatment for patients and is performed through dopaminergic …

Non-motor features of Parkinson disease

AHV Schapira, KR Chaudhuri, P Jenner - Nature Reviews …, 2017 - nature.com
Many of the motor symptoms of Parkinson disease (PD) can be preceded, sometimes for
several years, by non-motor symptoms that include hyposmia, sleep disorders, depression …

Treatment options for motor and non-motor symptoms of Parkinson's disease

FC Church - Biomolecules, 2021 - mdpi.com
Parkinson's disease (PD) usually presents in older adults and typically has both motor and
non-motor dysfunctions. PD is a progressive neurodegenerative disorder resulting from …

The SH-SY5Y cell line in Parkinson's disease research: a systematic review

H Xicoy, B Wieringa, GJM Martens - Molecular neurodegeneration, 2017 - Springer
Parkinson's disease (PD) is a devastating and highly prevalent neurodegenerative disease
for which only symptomatic treatment is available. In order to develop a truly effective …