Members of the CCN family of matricellular proteins are crucial for embryonic development
and have important roles in inflammation, wound healing and injury repair in adulthood …

Abstract CCN1 (CYR61) is a dynamically expressed, multifunctional matricellular protein
that plays essential roles in cardiovascular development during embryogenesis, and …

Cellular senescence is a recognized mechanism of tumour suppression; however, its
contribution to other pathologies is not well understood. We show that the matricellular …

Members of the CCN (CYR61/CTGF/NOV) family have emerged as dynamically expressed,
extracellular matrix-associated proteins that play critical roles in cardiovascular and skeletal …

The CCN family is a group of six secreted proteins that specifically associate with the
extracellular matrix. Structurally, CCN proteins are modular, containing up to four distinct …

The CCN proteins are key signalling and regulatory molecules involved in many vital
biological functions, including cell proliferation, angiogenesis, tumourigenesis and wound …

Liver fibrosis occurs as a wound-healing response to chronic hepatic injuries irrespective of
the underlying etiology and may progress to life-threatening cirrhosis. Here we show that …

Abstract The CCN family (CYR61; CTGF; NOV; CCN1–6; WISP1–3) of matricellular proteins
in mammals is comprised of six homologous members that play important roles in …

Neutrophil infiltration constitutes the first step in wound healing, although their timely
clearance by macrophage engulfment, or efferocytosis, is critical for efficient tissue repair …

Endometriosis, defined as the presence of endometrial tissue outside the uterus, is an
estrogen-dependent disease which causes pelvic pain and subfertility in women of …