Organotypic and microphysiological human tissue models for drug discovery and development—current state-of-the-art and future perspectives

S Youhanna, AM Kemas, L Preiss, Y Zhou… - Pharmacological …, 2022 - ASPET
The number of successful drug development projects has been stagnant for decades
despite major breakthroughs in chemistry, molecular biology, and genetics. Unreliable target …

Renoprotective effect of KLF2 on glomerular endothelial dysfunction in hypertensive nephropathy

E Bae, MY Yu, JJ Moon, JE Kim, S Lee, SW Han… - Cells, 2022 - mdpi.com
Kruppel-like factor 2 (KLF2) regulates endothelial cell metabolism; endothelial dysfunction is
associated with hypertension and is a predictor of atherosclerosis development and …

Intestinal microbiota by angiotensin receptor blocker therapy exerts protective effects against hypertensive damages

J Li, SY Wang, KX Yan, P Wang, J Jiao, YD Wang… - iMeta, 2024 - Wiley Online Library
Dysbiosis of the gut microbiota has been implicated in hypertension, and drug–host–
microbiome interactions have drawn considerable attention. However, the influence of …

Protective effect of Cyclo (His‐Pro) on peritoneal fibrosis through regulation of HDAC3 expression

JE Kim, D Han, KH Kim, A Seo, JJ Moon… - The FASEB …, 2024 - Wiley Online Library
Peritoneal dialysis is a common treatment for end‐stage renal disease, but complications
often force its discontinuation. Preventive treatments for peritoneal inflammation and fibrosis …

[HTML][HTML] Снижение функции почек при артериальной гипертензии у лиц молодого возраста: систематический обзор

АД Худякова, ЮИ Рагино - Артериальная гипертензия, 2021 - cyberleninka.ru
Целью систематического обзора являлось найти ответ на вопрос:«Влияет ли
повышение артериального давления на функцию почек в молодом возрасте?» …

Reduced renal function in hypertension in young adults: a systematic review

AD Khudiakova, YI Ragino - " Arterial'naya Gipertenziya"(" …, 2022 - htn.almazovcentre.ru
Objective. The aim of the systematic review was to find an answer to the question:«does an
increased blood pressure affect kidney function at young age?». Design and methods. The …