Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus
infection, mediating the transcriptional induction of type I interferons and other genes that …

Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …

RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …

Pattern recognition receptors (PRRs) survey intra-and extracellular spaces for pathogen-
associated molecular patterns (PAMPs) within microbial products of infection. Recognition …

Innate immunity against pathogens relies on an array of immune receptors to detect
molecular patterns that are characteristic of the pathogens, including receptors that are …

Viruses survive often harsh host environments, yet we know little about the strategies they
utilize to adapt and subsist given their limited genomic resources. We are beginning to …

Antiviral immunity is initiated upon host recognition of viral products via non-self molecular
patterns known as pathogen-associated molecular patterns (PAMPs). Such recognition …

The innate RNA sensor RIG-I is critical in the initiation of antiviral type I interferons (IFNs)
production upon recognition of" non-self" viral RNAs. Here, we identify a host-derived, IFN …

The Cas9/guide RNA (Cas9/gRNA) system is commonly used for genome editing. mRNA
expressing Cas9 can induce innate immune responses, reducing Cas9 expression. First …

Highlights•RLRs recognize viral non-self RNA with differential molecular machinery.•
Cytoplasmic aggregates containing RLRs are formed in response to viral dsRNA.•Ubiquitin …