ETS proteins are a group of evolutionarily related, DNA-binding transcriptional factors.
These proteins direct gene expression in diverse normal and disease states by binding to …

The transcription factors that regulate endothelial cell development have been a focus of
active research for several years, and many players in the endothelial transcriptional …

In this study we describe a model system that allows continuous in vivo observation of the
vertebrate embryonic vasculature. We find that the zebrafish fli1 promoter is able to drive …

In vertebrates, hematopoietic and vascular progenitors develop from ventral mesoderm. The
first primitive wave of hematopoiesis yields embryonic red blood cells, whereas progenitor …

Ewing's sarcoma is a highly aggressive bone and soft tissue tumor of children and young
adults. At the molecular genetic level Ewing's sarcoma is characterized by a balanced …

Sarcomas account for less than 10% of all human malignancies that are believed to
originate from as yet poorly defined mesenchymal progenitor cells. They constitute some of …

The ETS gene Fli-1 is involved in the induction of erythroleukemia in mice by Friend murine
leukemia virus and Ewings sarcoma in children. Mice with a targeted null mutation in the Fli …

During recent years, several significant discoveries have been made concerning the
function of ETS-domain transcription factors. This family of transcription factors was originally …

Tumor-associated chromosomal translocations lead to the formation of chimeric fusions
between the EWS gene and one of five different ETS transcription factors in Ewing's family …

Publisher Summary The discovery of ets proteins as transcription factors provided a
framework for understanding the oncogenic potential of ets genes. Ets proteins became a …