Epithelial cells require apical–basal plasma membrane polarity to carry out crucial vectorial
transport functions and cytoplasmic polarity to generate different cell progenies for tissue …

In the past decade, studies of the human tumour suppressor LKB1 have uncovered a novel
signalling pathway that links cell metabolism to growth control and cell polarity. LKB1 …

Majorana fermions are particles identical to their own antiparticles. They have been
theoretically predicted to exist in topological superconductors. Here, we report electrical …

We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the
pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and activates AMP …

The success of Drosophila melanogaster as a model organism is largely due to the power of
forward genetic screens to identify the genes that are involved in a biological process …

Germ cells play a unique role in gamete production, heredity and evolution. Therefore, to
understand the mechanisms that specify germ cells is a central challenge in developmental …

Interaction between endothelial cells and mural cells (pericytes and vascular smooth
muscle) is essential for vascular development and maintenance,,,. Endothelial cells arise …

The par genes were discovered in genetic screens for regulators of cytoplasmic partitioning
in the early embryo of C. elegans, and encode six different proteins required for asymmetric …

This review focuses on remarkable recent findings concerning the mechanism by which the
LKB1 protein kinase that is mutated in Peutz-Jeghers cancer syndrome operates as a tumor …

Ten years ago, par-1 and par-3 were cloned as two of the six par genes essential for the
asymmetric division of the Caenorhabditis elegans zygote. PAR-1 is a protein kinase …