Growth hormone (GH) and insulin-like growth factor 1 (IGF1) are important regulators of
bone remodelling and metabolism and have an essential role in the achievement and …

Mice are widely used in studies of skeletal biology, and assessment of their bones by
mechanical testing is a critical step when evaluating the functional effects of an experimental …

The discovery of the growth hormone (GH)-mediated somatic factors (somatomedins),
insulin-like growth factor (IGF)-I and-II, has elicited an enormous interest primarily among …

Background. Growth hormone (GH) and insulin‐like growth factor (IGF‐1) are fundamental
in skeletal growth during puberty and bone health throughout life. GH increases tissue …

Growth hormone (GH) and its mediator, the insulin-like growth factor-1 (IGF-1) regulate
somatic growth, metabolism and many aspects of aging. As such, actions of GH/IGF have …

Over the past three decades, the mainstay of treatment for osteoporosis has been
antiresorptive agents (such as bisphosphonates), which have been effective with continued …

Insulin-like growth factor I (IGF-1) is a key regulator of tissue growth and development in
response to growth hormone stimulation. In the skeletal system, IGF-1 derived from …

Osteoporosis is defined as low bone mineral density associated with skeletal fractures
secondary to minimal or no trauma, most often involving the spine, the hip, and the forearm …

Objective Age-related bone loss is associated with significant changes in bone remodeling
characterized by decreased trabecular and periosteal bone formation relative to bone …

The growth hormone (GH) and its downstream mediator, the insulin-like growth factor-1 (IGF-
1), construct a pleotropic axis affecting growth, metabolism, and organ function. Serum …