The quest to slow ageing through drug discovery

L Partridge, M Fuentealba, BK Kennedy - Nature Reviews Drug …, 2020 - nature.com
Although death is inevitable, individuals have long sought to alter the course of the ageing
process. Indeed, ageing has proved to be modifiable; by intervening in biological systems …

[HTML][HTML] An important polysaccharide from fermentum

B Lin, G Huang - Food Chemistry: X, 2022 - Elsevier
Fermentum is a common unicellular fungus with many biological activities attributed to β-
polysaccharides. Different in vivo and in vivo experimental studies have long proven that …

Modes‐of‐action of antifungal compounds: Stressors and (target‐site‐specific) toxins, toxicants, or toxin–stressors

D Noel, JE Hallsworth, E Gelhaye… - Microbial …, 2023 - Wiley Online Library
Fungi and antifungal compounds are relevant to the United Nation's Sustainable
Development Goals. However, the modes‐of‐action of antifungals—whether they are …

Correlations between microbiota bioactivity and bioavailability of functional compounds: A mini-review

E Vamanu, F Gatea - Biomedicines, 2020 - mdpi.com
Numerous studies have demonstrated the role of the microbiota in supporting the
physiological functions, owing to its metabolomic component. The presence of …

The potential of calorie restriction and calorie restriction mimetics in delaying aging: Focus on experimental models

E Giacomello, L Toniolo - Nutrients, 2021 - mdpi.com
Aging is a biological process determined by multiple cellular mechanisms, such as genomic
instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient …

The flavonoid corylin exhibits lifespan extension properties in mouse

TH Wang, WC Tseng, YL Leu, CY Chen… - Nature …, 2022 - nature.com
In the long history of traditional Chinese medicine, single herbs and complex formulas have
been suggested to increase lifespan. However, the identification of single molecules …

The bioactive potential of functional products and bioavailability of phenolic compounds

CM Dabulici, I Sârbu, E Vamanu - Foods, 2020 - mdpi.com
The expression of bioactivity depends on the assimilation of different classes of natural
substances (eg, phenolic compounds) in vivo. Six functional extracts (Aspalathus linearis …

The janus-faced role of lipid droplets in aging: insights from the cellular perspective

N Bresgen, M Kovacs, A Lahnsteiner, TK Felder… - Biomolecules, 2023 - mdpi.com
It is widely accepted that nine hallmarks—including mitochondrial dysfunction, epigenetic
alterations, and loss of proteostasis—exist that describe the cellular aging process. Adding …

[HTML][HTML] Curcumin inhibits TORC1 and prolongs the lifespan of cells with mitochondrial dysfunction

A Naaz, Y Zhang, NA Faidzinn, S Yogasundaram… - Cells, 2024 - mdpi.com
Aging is an inevitable biological process that contributes to the onset of age-related
diseases, often as a result of mitochondrial dysfunction. Understanding the mechanisms …

Flavonoids from sacred lotus stamen extract slows chronological aging in yeast model by reducing oxidative stress and maintaining cellular metabolism

D Tungmunnithum, S Drouet, C Hano - Cells, 2022 - mdpi.com
Nelumbo nucifera is one of the most valuable medicinal species of the Nelumbonaceae
family that has been consumed since the ancient historic period. Its stamen is an …