Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

Oocyte quality affects early embryonic survival, the establishment and maintenance of
pregnancy, fetal development, and even adult disease. Quality, or developmental …

When we edited in 2007 the first issue on transient receptor potential channel in the
Handbook of Experimental Pharmacology, we were all very excited by the progress in this …

Oocyte competence is the ability of the oocyte to complete maturation, undergo successful
fertilization, and reach the blastocyst stage. Cumulus cells are indispensable for this …

Neural stem cells (NSCs) reside in a unique microenvironment called the neurogenic niche
and generate functional new neurons. The neurogenic niche contains several distinct types …

It has been exciting times since the identification of polycystic kidney disease 1 (PKD1) and
PKD2 as the genes mutated in autosomal dominant polycystic kidney disease (ADPKD) …

The differentiation of the female gamete into a developmentally competent oocyte relies on
the protected environment of the ovarian follicle. The oocyte plays a key role in establishing …

The founding member of the TRPP family, TRPP2, was identified as one of the disease
genes causing autosomal dominant polycystic kidney disease (ADPKD). ADPKD is the most …

Folliculogenesis is the process by which the female germ cell develops within the somatic
cells of the ovary and matures into a fertilizable egg (1, 2). The development of the follicle is …

Combining cryopreservation of immature oocytes with in-vitro growth/maturation techniques
is the ambition of many IVF clinics. Whilst these techniques have been demonstrated in …