The normobaric oxygen paradox—hyperoxic hypoxic paradox: a novel expedient strategy in hematopoiesis clinical issues

M Salvagno, G Coppalini, FS Taccone… - International journal of …, 2022 - mdpi.com
Hypoxia, even at non-lethal levels, is one of the most stressful events for all aerobic
organisms as it significantly affects a wide spectrum of physiological functions and energy …

Oxidative stress response kinetics after 60 minutes at different (1.4 ATA and 2.5 ATA) hyperbaric hyperoxia exposures

C Leveque, S Mrakic Sposta, S Theunissen… - International journal of …, 2023 - mdpi.com
Hyperbaric oxygen therapy (HBOT) is a therapeutical approach based on exposure to pure
oxygen in an augmented atmospheric pressure. Although it has been used for years, the …

Oxy-inflammation in humans during underwater activities

A Vezzoli, S Mrakic-Sposta, A Brizzolari… - International journal of …, 2024 - mdpi.com
Underwater activities are characterized by an imbalance between reactive oxygen/nitrogen
species (RONS) and antioxidant mechanisms, which can be associated with an …

Elevations of extracellular vesicles and inflammatory biomarkers in closed circuit SCUBA divers

AK Arya, C Balestra, VM Bhopale, LJ Tuominen… - International journal of …, 2023 - mdpi.com
Blood-borne extracellular vesicles and inflammatory mediators were evaluated in divers
using a closed circuit rebreathing apparatus and custom-mixed gases to diminish some …

Oxidative stress response's kinetics after 60 minutes at different (30% or 100%) normobaric hyperoxia exposures

C Leveque, S Mrakic-Sposta, P Lafère… - International journal of …, 2022 - mdpi.com
Oxygen is a powerful trigger for cellular reactions and is used in many pathologies, including
oxidative stress. However, the effects of oxygen over time and at different partial pressures …

Oxidative Stress Response Kinetics after 60 Minutes at Different Levels (10% or 15%) of Normobaric Hypoxia Exposure

C Leveque, S Mrakic Sposta, S Theunissen… - International journal of …, 2023 - mdpi.com
In this study, the metabolic responses of hypoxic breathing for 1 h to inspired fractions of
10% and 15% oxygen were investigated. To this end, 14 healthy nonsmoking subjects (6 …

Pulsed hyperoxia acts on plasmatic advanced glycation end products and advanced oxidation protein products and modulates mitochondrial biogenesis in human …

C Balestra, S Baldelli, F Virgili, M Salvagno… - International Journal of …, 2024 - mdpi.com
The “normobaric oxygen paradox”(NOP) describes the response to the return to normoxia
after a hyperoxic event, sensed by tissues as an oxygen shortage, up-regulating redox …

The “ON-OFF” Switching Response of Reactive Oxygen Species in Acute Normobaric Hypoxia: Preliminary Outcome

S Mrakic-Sposta, M Gussoni, M Marzorati… - International journal of …, 2023 - mdpi.com
Exposure to acute normobaric hypoxia (NH) elicits reactive oxygen species (ROS)
accumulation, whose production kinetics and oxidative damage were here investigated …

Vascular function recovery following saturation diving

JP Imbert, SM Egi, C Balestra - Medicina, 2022 - mdpi.com
Background and Objectives: Saturation diving is a technique used in commercial diving.
Decompression sickness (DCS) was the main concern of saturation safety, but procedures …

Neuroinflammation with increased glymphatic flow in a murine model of decompression sickness

SR Thom, VM Bhopale, AR Bhat… - Journal of …, 2023 - journals.physiology.org
This project investigated glial-based lymphatic (glymphatic) function and its role in a murine
model of decompression sickness (DCS). DCS pathophysiology is traditionally viewed as …