BACKGROUND Biomolecules can serve as natural labels for microscopy by measuring their
molecular vibration spectra in living cells and tissues. However, the transition from …

Advancements in coherent Raman scattering (CRS) microscopy have enabled label-free
visualization and analysis of functional, endogenous biomolecules in living systems. When …

Raman scattering provides an intrinsic fingerprint of chemical composition. Spontaneous
Raman spectroscopy has been used for many decades to interrogate biological materials …

Spectroscopic imaging has been an increasingly critical approach for unveiling specific
molecules in biological environments. Toward this goal, we demonstrate hyperspectral …

Coherent anti-Stokes Raman scattering (CARS) microscopy can provide high resolution,
high speed, high sensitivity, and non-invasive imaging of specific biomolecules without …

Multidomain peptide (MDP) hydrogels are a class of self-assembling materials that have
been shown to elicit beneficial responses for soft tissue regeneration. However, their …

The study of amyotrophic lateral sclerosis (ALS) and potential interventions would be
facilitated if motor axon degeneration could be more readily visualized. Here we …

Characterizing precisely the microstructure of axons, their density, size and myelination is of
interest for the neuroscientific community, for example to help maximize the outcome of …

Current molecular analysis of cells and tissues routinely relies on separation, enrichment,
and subsequent measurements by various assays. Here we demonstrate a platform of …

Mitochondria are critical for the function and maintenance of myelinated axons notably
through Adenosine triphosphate (ATP) production. A direct by-product of this ATP production …