Hematopoietic stem cells (HSCs) possess two important properties such as self-renewal and
differentiation. These properties of HSCs are maintained through hematopoiesis. This …

Somatically acquired genetic abnormalities lead to the salient features that define
myelodysplastic syndromes (MDS): clonal hematopoiesis, aberrant differentiation …

Gene-modified autologous hematopoietic stem cells (HSC) can provide ample clinical
benefits to subjects suffering from X-linked chronic granulomatous disease (X-CGD), a rare …

Chromosomal inversion between 3q21 and 3q26 results in high-risk acute myeloid leukemia
(AML). In this study, we identified a mechanism whereby a GATA2 distal hematopoietic …

Members of the Prdm family are characterized by an N-terminal PR domain that is related to
the SET methyltransferase domain, and multiple zinc fingers that mediate sequence-specific …

The PRDM family has recently spawned considerable interest as it has been implicated in
fundamental aspects of cellular differentiation and exhibits expanding ties to human …

Ecotropic viral integration site 1 (Evi1), a transcription factor of the SET/PR domain protein
family, is essential for the maintenance of hematopoietic stem cells (HSCs) in mice and is …

Radioulnar synostosis with amegakaryocytic thrombocytopenia (RUSAT) is an inherited
bone marrow failure syndrome, characterized by thrombocytopenia and congenital fusion of …

Ecotropic viral integration site 1 (Evi1) was discovered in 1988 as a common site of
ecotropic viral integration resulting in myeloid malignancies in mice. EVI1 is an oncogenic …

Karyotype is one of the main constituents of the International Prognostic Scoring System
(IPSS) and revised-IPSS that are the cornerstones for the prognostication of patients with …