Many approaches have been used in the effective management of type 2 diabetes mellitus.
A recent paradigm shift has focused on the role of adipose tissues in the development and …

The maintenance of iron homeostasis is essential for proper endocrine function. A growing
body of evidence suggests that iron imbalance is a key factor in the development of several …

Age is the most important risk factor for most diseases. Mitochondria play a central role in
bioenergetics and metabolism. In addition, several lines of evidence indicate the impact of …

Overall excess of fat, usually defined by the body mass index, is associated with metabolic
(eg. glucose intolerance, type 2 diabetes mellitus (T2DM), dyslipidemia) and non-metabolic …

Bioenergetics has become central to our understanding of pathological mechanisms, the
development of new therapeutic strategies and as a biomarker for disease progression in …

Mitochondria play a key role in energy metabolism in many tissues, including cardiac and
skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be …

Fibroblast-like synoviocytes (FLSs) are a major cell population of the pannus that invades
cartilage and bone in rheumatoid arthritis (RA). FLS resistance to apoptosis is a major …

Adipose tissue, including white adipose tissue (WAT), brown adipose tissue (BAT), and
beige adipose tissue, is vital in modulating whole-body energy metabolism. While WAT …

The rise in obesity over the last several decades has reached pandemic proportions. Brown
adipose tissue (BAT) is a thermogenic organ that is involved in energy expenditure and …

Obesity is not necessarily a predisposing factor for disease. It is the handling of fat and/or
excessive energy intake that encompasses the linkage of inflammation, oxidation, and …