Circadian rhythm dysregulation and restoration: the role of melatonin

C Vasey, J McBride, K Penta - Nutrients, 2021 - mdpi.com
Sleep is an essential component of overall human health but is so tightly regulated that
when disrupted can cause or worsen certain ailments. An important part of this process is …

Nanotechnology-based ocular drug delivery systems: recent advances and future prospects

S Li, L Chen, Y Fu - Journal of Nanobiotechnology, 2023 - Springer
Ocular drug delivery has constantly challenged ophthalmologists and drug delivery
scientists due to various anatomical and physiological barriers. Static and dynamic ocular …

Melatonin in cancer treatment: current knowledge and future opportunities

WH Talib, AR Alsayed, A Abuawad, S Daoud… - Molecules, 2021 - mdpi.com
Melatonin is a pleotropic molecule with numerous biological activities. Epidemiological and
experimental studies have documented that melatonin could inhibit different types of cancer …

Melatonin in medicinal and food plants: Occurrence, bioavailability, and health potential for humans

B Salehi, F Sharopov, PVT Fokou, A Kobylinska… - Cells, 2019 - mdpi.com
Melatonin is a widespread molecule among living organisms involved in multiple biological,
hormonal, and physiological processes at cellular, tissue, and organic levels. It is well …

[HTML][HTML] Effects of coffee and its components on the gastrointestinal tract and the brain–gut axis

A Iriondo-DeHond, JA Uranga, MD Del Castillo… - Nutrients, 2021 - mdpi.com
Coffee is one of the most popular beverages consumed worldwide. Roasted coffee is a
complex mixture of thousands of bioactive compounds, and some of them have numerous …

[HTML][HTML] The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease

S Shen, Q Liao, YK Wong, X Chen, C Yang… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
In type 2 diabetes mellitus (T2DM) and its related disorders like obesity, the abnormal
protein processing, oxidative stress and proinflammatory cytokines will drive the activation of …

Melatonin: from pharmacokinetics to clinical use in autism spectrum disorder

S Lalanne, C Fougerou-Leurent, GM Anderson… - International Journal of …, 2021 - mdpi.com
The role of melatonin has been extensively investigated in pathophysiological conditions,
including autism spectrum disorder (ASD). Reduced melatonin secretion has been reported …

[HTML][HTML] Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology

A Panossian, EJ Seo, T Efferth - Phytomedicine, 2018 - Elsevier
Introduction Adaptogens are natural compounds or plant extracts that increase adaptability
and survival of organisms under stress. Adaptogens stimulate cellular and organismal …

[HTML][HTML] Melatonin for the treatment of sepsis: the scientific rationale

RMLC Biancatelli, M Berrill… - Journal of thoracic …, 2020 - ncbi.nlm.nih.gov
Sepsis affects 30 million people worldwide, leading to 6 million deaths every year (WHO),
and despite decades of research, novel initiatives are drastically needed. According to the …

The role of adaptogens in prophylaxis and treatment of viral respiratory infections

A Panossian, T Brendler - Pharmaceuticals, 2020 - mdpi.com
The aim of our review is to demonstrate the potential of herbal preparations, specifically
adaptogens for prevention and treatment of respiratory infections, as well as convalescence …